A7687
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A7687
Sigma
Aloe-emodin
≥95% (HPLC)
| Synonym: | 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone |
| CAS Number: | 481-72-1 |
| Linear Formula: | C15H10O5 |
| Molecular Weight: | 270.24 |
| Beilstein Registry Number: | 2059062 |
| EC Number: | 207-571-7 |
| MDL number: | MFCD00017373 |
| PubChem Substance ID: | 24891267 |
Description
| Biochem/physiol Actions | Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin. |
Properties
| assay | ≥95% (HPLC) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | CB6712200 |
References
| reference | Ali, S., et al., The stimulant cathartic, emodin, contracts the rat isolated ileum by triggering release of endogenous acetylcholine. Auton. Autocoid Pharmacol. 24, 103-105, (2004) |
| Jing, X., et al., Induction of apoptosis in hepatocellular carcinoma cell lines by emodin. Jpn. J. Cancer Res. 93, 874-882, (2002) | |
| Mueller, S.O., and Stopper, H., Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim. Biophys. Acta 1428, 406-414, (1999) |
